QMRA | Experiment ID | Acanth_Intranasal_Pooled |
|---|---|
| Pathogen | |
| Contains Preferred Model | 1 |
| Status | pooled |
| Host type | |
|---|---|
| # of Doses | 9.00 |
| Μodel | |
| a | 0.245 |
| N50 | 19357 |
| Dose Units | |
| Response | |
| Agent Strain | A. castellanii HN-3 and A culbertsoni A1 |
| Exposure Route | |
| Experiment Dataset | |
| Resampled Parameters |
The same exposure route and endpoint was evaluated for Experiments 3 and 4 (Cerva, 1967b; Culbertson et al. 1966)[6] [5]. A pooling analysis was attempted and successful. The beta-Poisson model provided a good fit to the pooled data and is shown below in Figure 1. Note: both the exact and approximate beta-Poisson models were fit to the data. The figures shown below and the csv file of bootstrapped parameter replicates are for the best fitting parameters of the exact beta-Poisson model. The successful pooling of multiple datasets generally increases the confidence in the estimated model parameters.
Figure 1: Plot of the beta-Poisson model fit to the pooled Experiments 3 and 4 with upper and lower 95% and 99% confidence
Figure 2: Uncertainty plot of the 10,000 paired bootstrap replicates of alpha and beta for the pooled beta-Poisson model.
[6] Cerva, L. (1967b). Intranasal, Intrapulmonary, and Intracardial Inoculation of Experimental Animals with Hartmanella castellanii. Folia Parasitologica (Praha), 14, 207–215.
[5] Culbertson, C. G., Ensminger, P. W., & Overton, W. M. (1966). Hartmannella (Acanthamoeba): Experimental Chronic, Granulomatous Brain Infections Produced by New Isolates of Low Virulence. The American Journal of Clinical Pathology, 46(3), 305–314.