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Experiment ID
21
Pathogen
Burkholderia mallei
Contains Preferred Model
0
Reference
Studies on Certain Biological Characteristics of Malleomyces mallei and Malleomyces pseudomallei
Host type
guinea pig
# of Doses
6.00
Μodel
beta-Poisson
a
2.67E-01
N50
2.55E+02
LD50/ID50
2.55E+02
Dose Units
CFU
Response
death
Agent Strain
W294
Exposure Route
intraperitoneal
Experiment Dataset
Description: 
Guinea Pigs W294 Strain Data [1]
Dose Dead Survived Total
44 1 4 5
440 3 2 5
4400 4 1 5
44000 5 0 5
440000 5 0 5
4.4E+06 4 1 5

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value		 χ20.95,m-k 
p-value
Exponential 70.3 66.1 5 3.84 
4.44e-16		 11.1 
8.93e-14
Beta Poisson 4.14 4 9.49 
0.387
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 2.67E-01 3.36E-02 8.80E-02 1.16E-01 1.05E+01 3.45E+02 3.55E+03
N50 2.55E+02 4.80E-07 2.49E+00 1.48E+01 1.35E+03 1.80E+03 3.22E+03

 

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

beta Poisson model plot, with confidence bounds around optimized model

References