Experiment ID
Acanth_Cornea2
Pathogen
Contains Preferred Model
0
Status
fitted
Host type
# of Doses
4.00
Μodel
k
3.63E-04
Dose Units
Response
Agent Strain
Acanthamoeba Ac118
Exposure Route
Experiment Dataset
Dose-Response Experimental Data in Mice
Dose (no. of organisms)Positive ResponseNegative ResponseTotal Subjects/Responses
10088
10001616
100071724
1000010010
Resampled Parameters
Description: 

Badenoch et al. (1990) studied the combined effect of Acanthamoeba Ac118 (a group III isolate) and the bacterium Corynebacterium xerosis on the corneas of female Portion rats. A constant dose of 106 C. xerosis with increasing doses of Acanthamoeba spp. were injected into incisions in the rat corneas using a microsyringe (Badenoch et al. 1990).

The exponential model provided the best fit to the data. 

Fig. 1: Plot of exponential model fit to Experiment 2 with upper and lower 95% and 99% confidence

Fig. 2: Histogram of the 10,000 bootstrap replicates of k for the best fitting exponential model fit to Experiment 2

Badenoch, P. R., Johnson, A. M., Christy, P. E., & Coster, D. J. (1990). Pathogenicity of Acanthamoeba and a Corynebacterium in the Rat Cornea. Archives of Ophthalmology, 108(1), 107–112. https://doi.org/10.1001/archopht.1990.01070030113040