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Experiment ID
21,23
Pathogen
Burkholderia mallei
Contains Preferred Model
0
Reference
Studies on Certain Biological Characteristics of Malleomyces mallei and Malleomyces pseudomallei
Host type
guinea pig and diabetic rat
# of Doses
11.00
Μodel
beta-Poisson
a
2.13E-01
N50
4.77E+02
LD50/ID50
4.77E+02
Dose Units
CFU
Response
death
Agent Strain
W294, 316c
Exposure Route
intraperitoneal
Experiment Dataset
Description: 
Pooled data of guinea pig and diabetic rat [1] 
Dose DEATH NOT DEATH Total
44 1 4 5
440 3 2 5
3000 6 4 10
4400 4 1 5
3E+04 7 3 10
44000 5 0 5
3E+05 7 3 10
440000 5 0 5
3E+06 10 0 10
4.4E+06 4 1 5
3E+07 10 0 10

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value		 χ20.95,m-k 
p-value
Exponential 163 152 10 3.84 
0		 18.3 
0
Beta Poisson 10.1 9 16.9 
0.343
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 2.13E-01 9.14E-02 1.26E-01 1.39E-01 3.38E-01 3.76E-01 5.60E-01
N50 4.77E+02 3.04E+00 1.63E+01 7.19E+01 2.16E+03 2.75E+03 4.44E+03

 

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

 

beta Poisson model plot, with confidence bounds around optimized model

References