Experiment ID |
Acanth_Intranasal_Pooled
|
---|---|
Agent Strain |
A. castellanii HN-3 and A culbertsoni A1
|
Contains Preferred Model |
Yes
|
Exposure Route |
intranasal
|
Response |
death
|
Host type |
mice
|
||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
# of Doses |
9.00
|
||||||||||||||||||||
Dose Units |
no of trophozoites
|
||||||||||||||||||||
Μodel |
beta-Poisson
|
||||||||||||||||||||
a |
0.245
|
||||||||||||||||||||
N50 |
19357
|
||||||||||||||||||||
Resampled Parameters | |||||||||||||||||||||
Experiment Dataset |
|
The same exposure route and endpoint was evaluated for Experiments 3 and 4 (Cerva, 1967b; Culbertson et al. 1966)[6] [5]. A pooling analysis was attempted and successful. The beta-Poisson model provided a good fit to the pooled data and is shown below in Figure 1. Note: both the exact and approximate beta-Poisson models were fit to the data. The figures shown below and the csv file of bootstrapped parameter replicates are for the best fitting parameters of the exact beta-Poisson model. The successful pooling of multiple datasets generally increases the confidence in the estimated model parameters.
[6] Cerva, L. (1967b). Intranasal, Intrapulmonary, and Intracardial Inoculation of Experimental Animals with Hartmanella castellanii. Folia Parasitologica (Praha), 14, 207–215.
[5] Culbertson, C. G., Ensminger, P. W., & Overton, W. M. (1966). Hartmannella (Acanthamoeba): Experimental Chronic, Granulomatous Brain Infections Produced by New Isolates of Low Virulence. The American Journal of Clinical Pathology, 46(3), 305–314.