Submitted by admin on

Experiment ID
214, 216, 217
Pathogen
Escherichia coli
Agent Strain
EPEC B171-8 (serotype O11:NM)
Contains Preferred Model
No
Reference
Bieber, D. ., Ramer, S. W., C-y, W. ., Murray, W. J., Tobe, T. ., Fernandez, R. ., & Schoolnik, G. K. (1998). Type IV Pili, Transient Bacterial Aggregates, and Virulence of Enteropathogenic Escherichia coli. Science., 280, 5372.
Exposure Route
oral (with NaHCO3)
Response
diarrhea
Host type
human
# of Doses
8.00
Dose Units
CFU
Μodel
beta-Poisson
a
2.21E-01
N50
6.85E+07
LD50/ID50
6.85E+07
Experiment Dataset
Description
EPEC disease in the human model data
Dose Diarrhea No diarrhea Total
1E+06 0 4 4
1E+06 1 4 5
1E+08 1 4 5
5E+08 3 2 5
2.5E+09 6 0 6
1E+10 3 2 5
1E+10 5 0 5
2E+10 2 0 2

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential 31.8 20.6 7 3.84 
5.69e-06 		14.1 
4.37e-05
Beta Poisson 11.2 6 12.6 
0.0813
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 2.21E-01 9.31E-02 1.18E-01 1.27E-01 1.25E+00 7.41E+02 1.29E+04
N50 6.85E+07 6.14E+06 1.11E+07 1.52E+07 6.32E+08 7.69E+08 1.09E+09
Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.
Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.
beta Poisson model plot, with confidence bounds around optimized model
beta Poisson model plot, with confidence bounds around optimized model