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Experiment ID
954,955,956,957
Pathogen
Naegleria fowleri
Contains Preferred Model
No
Reference
Dean, K. ., Weir, M. H., & Mitchell, J. . (2018). Development of a dose–response model for Naegleria fowleri. Journal of Water and Health, 17, 63-71. https://doi.org/10.2166/wh.2018.181 (Original work published)
Exposure Route
Swimming for 5
10 or 20 minutes
Response
death
Host
CD1 Mice
# of Doses
13.00
Dose Units
no of trophozoites
Μodel
beta-Poisson
a
0.226
N50
5.79E+04
LD50/ID50
5.79E+04
Experiment Dataset
Description
Mice/Naegleria fowleri LEE strain data
Dose Dead Survived Total
1E+02 0 10 10
1E+02 0 10 10
1E+02 0 10 10
1E+03 0 10 10
1E+03 1 9 10
1E+03 1 9 10
1E+04 1 9 10
1E+04 4 6 10
1E+04 4 6 10
1E+05 4 6 10
1E+05 6 4 10
1E+05 7 3 10
1E+06 7 3 10

 

Goodness of fit for pooled data
Model Deviance Degrees 
of freedom

χ20.95,1

 

 χ20.95,m-k 
 
Beta Poisson 7.4 11 19.68 0.77
Plot of beta-Poisson model for pooled data of CD1 mice swimming for 5, 10, and 20 minutes with upper and lower 95% and 99% confidence.
Plot of beta-Poisson model for pooled data of CD1 mice swimming for 5, 10, and 20 minutes with upper and lower 95% and 99% confidence.
Bootstrapped distribution of beta-Poisson parameter estimates for pooled data of CD1 mice swimming for 5, 10, and 20 minutes; the center marker (X) represents the maximum likelihood estimate.
Bootstrapped distribution of beta-Poisson parameter estimates for pooled data of CD1 mice swimming for 5, 10, and 20 minutes; the center marker (X) represents the maximum likelihood estimate.