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Experiment ID
281
Pathogen
Pseudomonas aeruginosa
Agent Strain
ATCC 19660
Contains Preferred Model
No
Reference
Hazlett, L. D., Rosen, D. D., & Berk, R. S. (1978). Age-Related Susceptibility to Pseudomonas aeruginosa Ocular Infections in Mice. Infection and Immunity, 20, 1.
Exposure Route
injected in eyelids
Response
death
Host type
Swiss webster mice (5day old)
# of Doses
6.00
Dose Units
CFU
Μodel
exponential
k
8.52E-05
LD50/ID50
8.13E+03
Description
mice (5day old) /  Pseudomonas aeruginosa 
Dose Dead Survived Total
2.5 0 13 13
25 0 14 14
250 0 12 12
2500 4 13 17
25000 13 2 15
250000 17 0 17

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential

0.802

 0.0885 5 3.84 
0.766 		11.1 
0.977
Beta Poisson

0.713

 4 9.49 
0.95
Exponential is preferred to beta-Poisson; cannot reject good fit for exponential.

 

Optimized k parameter for the exponential model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
k 8.52E-05 4.21E-05 4.99E-05 5.50E-05 1.53E-04 1.57E-04 2.05E-04
ID50/LD50/ETC* 8.13E+03 3.38E+03 4.40E+03 4.54E+03 1.26E+04 1.39E+04 1.65E+04
*Not a parameter of the exponential model; however, it facilitates comparison with other models.

 

Parameter histogram for exponential model (uncertainty of the parameter)

Exponential model plot, with confidence bounds around optimized model

References