Submitted by kdean on

Experiment ID
Ojielo2003
Pathogen
Pseudomonas aeruginosa
Agent Strain
PA01
Contains Preferred Model
No
Reference
Ojielo, C. I., Cooke, K. ., Mancuso, P. ., Standiford, T. J., Olkiewicz, K. M., Clouthier, S. ., … Moore, B. B. (2003). Defective Phagocytosis and Clearance of <i>Pseudomonas aeruginosa</i> in the Lung Following Bone Marrow Transplantation. The Journal of Immunology, 171(8), 4416-4424. Retrieved from https://journals.aai.org/jimmunol/article/171/8/4416/35775/Defective-Phagocytosis-and-Clearance-of (Original work published)
Exposure Route
intratracheal
Response
death
Host type
C57BL/6 mice
# of Doses
7.00
Dose Units
CFU
Μodel
exponential
k
3.22E-7
Experiment Dataset
Dose (CFU) Positive Response Negative Response
80000 0 10
400000 0 10
900000 0 10
2000000 2 5
3000000 6 4
4500000 10 0
8000000 10 0
Description
Table 1: Goodness of fit
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential 16.88 0.001 6 3.84 
0.98 		12.6
0.009
Beta Poisson 16.88 5 11.1
0.004
Neither model provides a good fit to the data

 

Table 2: Multi-hit dose response statistics
Model Deviance Δ DF χ20.95,df χ20.95,1 Good fit? Parameters LD50
Multi-hit 1.09 15.69 5 11.1 3.84 Yes k = 4.12 × 10−6 kmin=11 2,588,047

 

Figure 1. The multi-hit dose response model with 95% and 99% confidence bands
Figure 1. The multi-hit dose response model with 95% and 99% confidence bands

 

 

Figure 2. Histogram of the k parameter estimates after bootstrapping
Figure 2. Histogram of the k parameter estimates after bootstrapping