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Experiment ID
260
Pathogen
SARS
Agent Strain
rSARS-CoV
Contains Preferred Model
No
Reference
Albuquerque, N. D., Baig, E. ., Ma, X. ., Zhang, J. ., He, W. ., Rowe, A. ., … Levy, G. A. (2006). Murine Hepatitis Virus Strain 1 Produces a Clinically Relevant Model of Severe Acute Respiratory Syndrome in A/J Mice. Journal of Virology, 80, 21. https://doi.org/10.1128/JVI.00747-06
Exposure Route
intranasal
Response
death
Host type
mice hACE-2
# of Doses
4.00
Dose Units
PFU
Μodel
exponential
k
2.97E-03
LD50/ID50
2.33E+02
Description
mice/rSARS-CoV strain model data [2]
Dose Dead Survived Total
240 1 2 3
800 3 0 3
2400 2 0 2
12000 6 0 6

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential 0.968 -0.000923 3 3.84 
1 		7.81 
0.809
Beta Poisson 0.969 2 5.99 
0.616
Exponential is preferred to beta-Poisson; cannot reject good fit for exponential.

 

Optimized k parameter for the exponential model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
k 2.97E-03 1.90E-03 1.90E-03 1.90E-03 2.97E-03 2.97E-03 2.97E-03
ID50/LD50/ETC* 2.33E+02 2.33E+02 2.33E+02 2.33E+02 3.64E+02 3.64E+02 3.64E+02
*Not a parameter of the exponential model; however, it facilitates comparison with other models.

 

Parameter histogram for exponential model (uncertainty of the parameter)

Exponential model plot, with confidence bounds around optimized model