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Experiment ID
261
Pathogen
SARS
Agent Strain
MHV-1
Contains Preferred Model
No
Reference
Albuquerque, N. D., Baig, E. ., Ma, X. ., Zhang, J. ., He, W. ., Rowe, A. ., … Levy, G. A. (2006). Murine Hepatitis Virus Strain 1 Produces a Clinically Relevant Model of Severe Acute Respiratory Syndrome in A/J Mice. Journal of Virology, 80, 21. https://doi.org/10.1128/JVI.00747-06
Exposure Route
intranasal
Response
death
Host type
A/J mice
# of Doses
4.00
Dose Units
PFU
Μodel
exponential
k
2.14E-03
LD50/ID50
3.24E+02
Description
Mice/MHV-1 strains model data [3]
Dose Dead Survived Total
5 0 5 5
50 1 4 5
500 3 2 5
5000 5 0 5

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential 0.606 0.0689 3 3.84 
0.793 		7.81 
0.895
Beta Poisson 0.537 2 5.99 
0.765
Exponential is preferred to beta-Poisson; cannot reject good fit for exponential.

 

Optimized k parameter for the exponential model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
k 2.14E-03 6.25E-04 6.55E-04 9.06E-04 6.58E-03 6.58E-03 9.86E-03
ID50/LD50/ETC* 3.24E+02 7.03E+01 1.05E+02 1.05E+02 7.65E+02 1.06E+03 1.11E+03
*Not a parameter of the exponential model; however, it facilitates comparison with other models.

 

Parameter histogram for exponential model (uncertainty of the parameter)

Exponential model plot, with confidence bounds around optimized model