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Experiment ID
298
Pathogen
Pseudomonas aeruginosa
Contains Preferred Model
No
Reference
Lawin-Brüssel, C. A., Refojo, M. F., Leong, F. L., Hanninen, L. ., & Kenyon, K. R. (1993). Effect of Pseudomonas aeruginosa concentration in experimental contact lens-related microbial keratitis. Cornea, 12, 1.
Exposure Route
contact lens
Response
Severe stromal ulceration
Host type
white rabbit
# of Doses
5.00
Dose Units
CFU
Μodel
beta-Poisson
a
1.09E-01
N50
1.52E+05
LD50/ID50
1.52E+05
Description
White rabbit /  Pseudomonas aeruginosa 
Dose Severe Stromal Ulceration

Not Corneal Ulceration

 Total
63.2 0 5 5
2220 2 3 5
13200 1 4 5
78000 1 4 5
462000 4 1 5

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential

13.2

 8.73 4 3.84 
0.00313  		9.49 
0.0105
Beta Poisson

4.43

 3 7.81 
0.219
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 1.09E-01 4.05E-02 5.23E-02 5.72E-02 9.05E+06 4.82E+07 2.53E+12
N50 1.52E+05 4.66E+03 1.13E+04 1.55E+04 1.55E+07 6.25E+07 1.96E+09

 

Parameter histogram for exponential model (uncertainty of the parameter)

Exponential model plot, with confidence bounds around optimized model

References