Table of contents

Introduction

Prion-related diseases are relentlessly progressive and invariably lead to death (Medscape)

Hosts

Human and animal [1]

Transmission / Exposure Route

Primary method of infection in animals is through ingestion[2]

Case Fatality Ratio

Prion-related diseases are relentlessly progressive and invariably lead to death. [2]

Incubation Period

Incubation periods of infection with human prions can exceed 50 years[3]

Burden of Disease

The most common prion disease is CJD, with a uniform incidence of approximately 1 case per million population both in the United States and internationally[2]

Duration of Infectiousness and disease

Symptomology

Latency

Asymptomatic Rates

Excretion Rates (see Exposure)

Immunity

Microbiology

An infectious agent composed of protein in a misfolded form

beta-Poisson

$$P(response)=1-[1+dose\frac{2^{\frac{1}{a}}-1}{N^{50}} ]^{-a}$$

Optimized parameters:
a = 1.76E+00
N50 = 1.04E+05
LD50 = 1.04E+05

Data from other sources:


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