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Experiment ID
259
Pathogen
Influenza
Agent Strain
H5N1, DKGX/35 strain
Contains Preferred Model
No
Reference
DeDiego, M. L., Pewe, L. ., Alvarez, E. ., Rejas, M. T., Perlman, S. ., & Enjuanes, L. . (2008). Pathogenicity of severe acute respiratory coronavirus deletion mutants in hACE-2 transgenic mice. Virology., 376, 2. https://doi.org/10.1016/j.virol.2008.03.005
Exposure Route
intranasal
Response
death
Host type
mice
# of Doses
6.00
Dose Units
EID50
Μodel
exponential
k
1.09E-02
LD50/ID50
6.38E+01
Description
mice/ H5N1,DKGX/35 strain model data [4]
Dose Dead Survived Total
10 1 4 5
100 3 2 5
1000 5 0 5
1E+04 5 0 5
1E+05 5 0 5
1E+06 5 0 5

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential 0.498 0.0917 5 3.84 
0.762 		11.1 
0.992
Beta Poisson 0.406 4 9.49 
0.982
Exponential is preferred to beta-Poisson; cannot reject good fit for exponential.

 

Optimized k parameter for the exponential model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
k 1.09E-02 3.14E-03 3.29E-03 4.56E-03 2.78E-02 3.48E-02 5.42E-02
ID50/LD50/ETC* 6.38E+01 1.28E+01 1.99E+01 2.49E+01 1.52E+02 2.11E+02 2.21E+02
*Not a parameter of the exponential model; however, it facilitates comparison with other models.

 

Parameter histogram for exponential model (uncertainty of the parameter)

Exponential model plot, with confidence bounds around optimized model