QMRA | Experiment ID | Acanth_Cornea2 |
|---|---|
| Pathogen | |
| Contains Preferred Model | 0 |
| Status | fitted |
| Reference |
| Host type | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| # of Doses | 4.00 | ||||||||||||||||||||
| Μodel | |||||||||||||||||||||
| k | 3.63E-04 | ||||||||||||||||||||
| LD50/ID50 | 1.91E+03 | ||||||||||||||||||||
| Dose Units | |||||||||||||||||||||
| Response | |||||||||||||||||||||
| Agent Strain | Acanthamoeba Ac118 | ||||||||||||||||||||
| Exposure Route | |||||||||||||||||||||
| Experiment Dataset |
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Description:
Badenoch et al. (1990) studied the combined effect of Acanthamoeba Ac118 (a group III isolate) and the bacterium Corynebacterium xerosis on the corneas of female Portion rats. A constant dose of 106 C. xerosis with increasing doses of Acanthamoeba spp. were injected into incisions in the rat corneas using a microsyringe[1].
The exponential model provided the best fit to the data.
Acanth_Cornea2.png
Fig. 1: Plot of exponential model fit to Experiment 2 with upper and lower 95% and 99% confidence
Acanth_Cornea2_boot.png
Fig. 2: Histogram of the 10,000 bootstrap replicates of k for the best fitting exponential model fit to Experiment 2