This amoeba is rare, but it can cause severe infections of the eye, skin, and central nervous system. It can cause three major infections: acanthamoeba keratitis, GAE, and disseminated infection. Acanthamoeba keratitis is an infection in the eye that can cause permanent visual impairment in healthy people. GAE is a serious brain and spinal cord infection that occurs in immunocompromised individuals. Disseminated infection is a widespread infection that affects the skin, sinuses, lungs, and other organs, which is more common in immunocompromised individuals.