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Home / Framework / Dose Response / Experiments / Cryptosporidium hominis: Dose Response Experiments
ID # of Doses Agent Strain Dose Units Host type Μodel Optimized parameters Response type Reference
108 8 Iowa strain oocysts human exponential
k = 4.19E-03
LD50/ID50 = 1.65E+02

infection DuPont, H. L., et al. "The infectivity of Cryptosporidium parvum in healthy volunteers." The New England journal of medicine. 332 (1995): 13.
139 8 Iowa isolate oocysts human exponential
k = 5.26E-03
LD50/ID50 = 1.32E+02

infection Messner, M. J., C. L. Chappell, and P. C. Okhuysen. "Risk Assessment for Cryptosporidium: A Hierarchical Bayesian Analysis of Human Dose Response Data." Water Research. 35 (2001): 16.
140 4 TAMU isolate oocysts human exponential
k = 5.72E-02
LD50/ID50 = 1.21E+01

infection Messner, M. J., C. L. Chappell, and P. C. Okhuysen. "Risk Assessment for Cryptosporidium: A Hierarchical Bayesian Analysis of Human Dose Response Data." Water Research. 35 (2001): 16.
141 4 UCP isolate oocysts human beta-Poisson a = 1.45E-01

LD50/ID50 = 1.79E+02
N50 = 1.79E+02
infection Coster, T. S., et al. "Immune response, ciprofloxacin activity, and gender differences after human experimental challenge by two strains of enterotoxigenic Escherichia coli." Infection and immunity. 75 (2007): 1.
181 4 *C. hominis*, TU502 oocysts human beta-Poisson a = 2.7E-01

LD50/ID50 = 1.68E+01
N50 = 1.68E+01
diarrhea Okhuysen, P. C., et al. "Infectivity of a Cryptosporidium parvum Isolate of Cervine Origin for Healthy Adults and Interferon-γ Knockout Mice." Journal of Infectious Diseases. 185 (2002): 9.
183 4 Moredun isolate oocysts human beta-Poisson a = 1.14E-01

LD50/ID50 = 4.55E+02
N50 = 4.55E+02
infection Blaser, M. J., et al. "Experimental Campylobacter jejuni Infection of Adult Mice." Infection and Immunity. 39 (1983): 2.
Experiment ID:
108
# of Doses:
8
Agent Strain:
Iowa strain
Dose Units:
oocysts
Host type:
human
Μodel:
exponential
Optimized parameters:
k = 4.19E-03
LD50/ID50 = 1.65E+02

Reference:
Experiment ID:
139
# of Doses:
8
Agent Strain:
Iowa isolate
Dose Units:
oocysts
Host type:
human
Μodel:
exponential
Optimized parameters:
k = 5.26E-03
LD50/ID50 = 1.32E+02

Reference:
Best Fit
Experiment ID:
140
# of Doses:
4
Agent Strain:
TAMU isolate
Dose Units:
oocysts
Host type:
human
Μodel:
exponential
Optimized parameters:
k = 5.72E-02
LD50/ID50 = 1.21E+01

Reference:
Experiment ID:
141
# of Doses:
4
Agent Strain:
UCP isolate
Dose Units:
oocysts
Host type:
human
Μodel:
beta-Poisson
Optimized parameters: a = 1.45E-01

LD50/ID50 = 1.79E+02
N50 = 1.79E+02
Reference:
Experiment ID:
181
# of Doses:
4
Agent Strain:
*C. hominis*, TU502
Dose Units:
oocysts
Host type:
human
Μodel:
beta-Poisson
Optimized parameters: a = 2.7E-01

LD50/ID50 = 1.68E+01
N50 = 1.68E+01
Reference:
Experiment ID:
183
# of Doses:
4
Agent Strain:
Moredun isolate
Dose Units:
oocysts
Host type:
human
Μodel:
beta-Poisson
Optimized parameters: a = 1.14E-01

LD50/ID50 = 4.55E+02
N50 = 4.55E+02
Reference: