General Overview
According to Stalkup and Chilukuri^{[1]}, enterovirus, a small (30 nm), nonenveloped, singlestranded RNA viruses, belongs to the family Picornaviridae. While most of the enterovirus infections are relatively mild and result in complete recovery of the patient, they can also cause severe and fatal diseases such as meningitis, encephalitis, myocarditis, neonatal sepsis, and polio like paralytic diseases. Infection occurs mainly via fecaloral transmission and less commonly by respiratory droplets. While no known nonhuman reservoirs have been identified, waterborne, foodborne, and bloodborne transmissions have been reported.
Summary Data
Cliver^{[2]} challenged pigs with Porcine enterovirus type 3 and 7 via oral exposure route.
ID  # of Doses  Agent Strain  Dose Units  Host type  Μodel  Optimized parameters  Response type  Reference 

62  3  porcine, PE3ECPO6  PFU  pig  exponential 
k = 2.96E04 LD_{50}/ID_{50} = 2.34E+03 
infection 
Cliver^{[2]} 
63  3  porcine, PE705i  PFU  pig  exponential 
k = 3.74E03 LD_{50}/ID_{50} = 1.85E+02 
infection 
Cliver^{[2]} 
Optimization Output for Exp. 62:
Experiment ID: 62
# of Doses: 3
Agent Strain: porcine, PE3ECPO6
Dose Units: PFU
Host type: pig
Μodel: exponential
Optimized parameters:
k = 2.96E04
LD_{50}/ID_{50} = 2.34E+03



Parameter histogram for exponential model (uncertainty of the parameter)
Exponential model plot, with confidence bounds around optimized model
Optimization Output for Exp. 63:
Best Fit
Experiment ID: 63
# of Doses: 3
Agent Strain: porcine, PE705i
Dose Units: PFU
Host type: pig
Μodel: exponential
Optimized parameters:
k = 3.74E03
LD_{50}/ID_{50} = 1.85E+02



Parameter histogram for exponential model (uncertainty of the parameter)
Exponential model plot, with confidence bounds around optimized model
Recommended Model
It is recommended that experiment 63 should be used as the best doseresponse model.
Summary
The different LD_{50} for these two experiments indicates that virulence varies between pathogen strains.
References
 Enterovirus infections: a review of clinical presentation, diagnosis, and treatment, , Dermatologic clinics, Volume 20, p.217–223, (2002)
 Experimental infection by waterborne enteroviruses, , Journal of Food Protection, Volume 44, Number 11, p.861–865, (1981)
ID  # of Doses  Agent Strain  Dose Units  Host type  Μodel  Optimized parameters  Response type  Reference 

62  3  porcine, PE3ECPO6  PFU  pig  exponential 
k = 2.96E04 LD_{50}/ID_{50} = 2.34E+03 
infection  Experimental infection by waterborne enteroviruses." Journal of Food Protection. 44 (1981): 861865.  "
63  3  porcine, PE705i  PFU  pig  exponential 
k = 3.74E03 LD_{50}/ID_{50} = 1.85E+02 
infection  Experimental infection by waterborne enteroviruses." Journal of Food Protection. 44 (1981): 861865.  "
k = 2.96E04
LD_{50}/ID_{50} = 2.34E+03



Parameter histogram for exponential model (uncertainty of the parameter)
Exponential model plot, with confidence bounds around optimized model
References
 Experimental infection by waterborne enteroviruses, , Journal of Food Protection, Volume 44, p.861865, (1981)
k = 3.74E03
LD_{50}/ID_{50} = 1.85E+02



Parameter histogram for exponential model (uncertainty of the parameter)
Exponential model plot, with confidence bounds around optimized model
References
 Experimental infection by waterborne enteroviruses, , Journal of Food Protection, Volume 44, p.861865, (1981)