General Overview
According to Stalkup and Chilukuri[1], enterovirus, a small (30 nm), nonenveloped, single-stranded RNA viruses, belongs to the family Picornaviridae. While most of the enterovirus infections are relatively mild and result in complete recovery of the patient, they can also cause severe and fatal diseases such as meningitis, encephalitis, myocarditis, neonatal sepsis, and polio like paralytic diseases. Infection occurs mainly via fecal-oral transmission and less commonly by respiratory droplets. While no known non-human reservoirs have been identified, water-borne, foodborne, and blood-borne transmissions have been reported.
Summary Data
Cliver[2] challenged pigs with Porcine enterovirus type 3 and 7 via oral exposure route.
ID | # of Doses | Agent Strain | Dose Units | Host type | Μodel | Optimized parameters | Response type | Reference |
---|---|---|---|---|---|---|---|---|
62 | 3 | porcine, PE3-ECPO-6 | PFU | pig | exponential |
k = 2.96E-04 LD50/ID50 = 2.34E+03 |
infection |
Cliver[2] |
63 | 3 | porcine, PE7-05i | PFU | pig | exponential |
k = 3.74E-03 LD50/ID50 = 1.85E+02 |
infection |
Cliver[2] |
Optimization Output for Exp. 62:
Experiment ID: 62
# of Doses: 3
Agent Strain: porcine, PE3-ECPO-6
Dose Units: PFU
Host type: pig
Μodel: exponential
Optimized parameters:
k = 2.96E-04
LD50/ID50 = 2.34E+03
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|
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Parameter histogram for exponential model (uncertainty of the parameter)
Exponential model plot, with confidence bounds around optimized model
Optimization Output for Exp. 63:
Best Fit
Experiment ID: 63
# of Doses: 3
Agent Strain: porcine, PE7-05i
Dose Units: PFU
Host type: pig
Μodel: exponential
Optimized parameters:
k = 3.74E-03
LD50/ID50 = 1.85E+02
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|
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Parameter histogram for exponential model (uncertainty of the parameter)
Exponential model plot, with confidence bounds around optimized model
Recommended Model
It is recommended that experiment 63 should be used as the best dose-response model.
Summary
The different LD50 for these two experiments indicates that virulence varies between pathogen strains.
References
ID | # of Doses | Agent Strain | Dose Units | Host type | Μodel | Optimized parameters | Response type | Reference |
---|---|---|---|---|---|---|---|---|
62 | 3 | porcine, PE3-ECPO-6 | PFU | pig | exponential |
k = 2.96E-04 LD50/ID50 = 2.34E+03 |
infection | Experimental infection by waterborne enteroviruses." Journal of Food Protection. 44 (1981): 861-865. | "
63 | 3 | porcine, PE7-05i | PFU | pig | exponential |
k = 3.74E-03 LD50/ID50 = 1.85E+02 |
infection | Experimental infection by waterborne enteroviruses." Journal of Food Protection. 44 (1981): 861-865. | "
k = 2.96E-04
LD50/ID50 = 2.34E+03
|
|
|
Parameter histogram for exponential model (uncertainty of the parameter)
Exponential model plot, with confidence bounds around optimized model
References
k = 3.74E-03
LD50/ID50 = 1.85E+02
|
|
|
Parameter histogram for exponential model (uncertainty of the parameter)
Exponential model plot, with confidence bounds around optimized model