Optimization Output for Exp. 241

Basic Information

Experiment ID	241
Pathogen	Legionella pneumophila
Contains Preferred Model	1
Reference	Aerosol infection of animals with strains of Legionella pneumophila of different virulence: comparison with intraperitoneal and intranasal routes of infection

Detailed information

Host type

# of Doses

4.00

Μodel

5.99E-02

LD50/ID50

1.16E+01

Dose Units

Response

Agent Strain

Philadelphia 1

Exposure Route

Experiment Dataset

Description:

**Goodness of fit and model selection**
Model	Deviance	Δ	Degrees of freedom	χ²_0.95,1 p-value	χ²_0.95,m-k p-value
Exponential	0.582	0.000479	3	3.84 0.983	7.81 0.9
Beta Poisson	0.582	0.000479	2	3.84 0.983	5.99 0.748
Exponential is preferred to beta-Poisson; cannot reject good fit for exponential.

**Optimized k parameter for the exponential model, from 10000 bootstrap iterations**
Parameter	MLE estimate	Percentiles
Parameter	MLE estimate	0.5%	2.5%	5%	95%	97.5%	99.5%
k	5.99E-02	3.26E-02	3.90E-02	4.18E-02	1.11E-01	1.31E-01	1.57E-01
ID50/LD50/ETC*	1.16E+01	4.42E+00	5.28E+00	6.25E+00	1.66E+01	1.78E+01	2.13E+01
*Not a parameter of the exponential model; however, it facilitates comparison with other models.

Parameter histogram for exponential model (uncertainty of the parameter)

Exponential model plot, with confidence bounds around optimized model

References