General Overview
Salmonella is a genus of rod-shaped, gram-negative, non-spore forming, predominantly motile enterobacteria (Chalker and Blaser 1988). Many species of Salmonella have been isolated from eggs and egg products (McCullough and Eisele 1951). Salmonella meleagridis is one of the most common serotype of Salmonella (Zaidi, McDermott et al. 2006). Twenty human isolates of S. meleagridis had been identified in Canada so far during 1997.
http://www.cdc.gov/salmonella/
Summary Data
McCullough, and Eisele (1951) inoculated human volunteers orally with the S. Meleagridis strain I,II and III.[1]
Recommended Model
Eexperiment number 238 is the recommended one as the strain I was more virulent than strain III.
ID | # of Doses | Agent Strain | Dose Units | Host type | Μodel | Optimized parameters | Response type | Reference |
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238 | 11 | strain I | CFU | human | beta-Poisson |
a = 3.89E-01 LD50/ID50 = 1.68E+04 N50 = 1.68E+04 |
infection | Experimental Human Salmonellosis: I." Pathogenicity of Strains of Salmonella meleagridis and Salmonella anatum Obtained from Spray-Dried Whole Egg. 88 (1951): 3. | "
240 | 4 | strain III | CFU | human | beta-Poisson |
a = 8.85E-01 LD50/ID50 = 5.24E+05 N50 = 5.24E+05 |
infection | Changes in Iron and Transferrin Levels and Body Temperature in Experimental Airborne Legionellosis." The Journal of Infectious Diseases. 147 (1983): 2. | "
LD50/ID50 = 1.68E+04
N50 = 1.68E+04
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Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.
beta Poisson model plot, with confidence bounds around optimized model
LD50/ID50 = 5.24E+05
N50 = 5.24E+05
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Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.
beta Poisson model plot, with confidence bounds around optimized model