QMRA | Experiment ID | Acanth_Cornea1 |
|---|---|
| Pathogen | |
| Contains Preferred Model | 0 |
| Status | fitted |
| Host type | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| # of Doses | 4.00 | ||||||||||||||||||||
| Μodel | |||||||||||||||||||||
| k | 1.01E-04 | ||||||||||||||||||||
| LD50/ID50 | 6,886 | ||||||||||||||||||||
| Dose Units | |||||||||||||||||||||
| Response | |||||||||||||||||||||
| Agent Strain | Acanthamoeba Ac118 | ||||||||||||||||||||
| Exposure Route | |||||||||||||||||||||
| Experiment Dataset |
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| Resampled Parameters |
Badenoch et al. (1990) studied the combined effect of Acanthamoeba Ac118 (a group III isolate) and the bacterium Corynebacterium xerosis on the corneas of female Porton rats. A constant dose of 104C. xerosis with increasing doses of Acanthamoeba spp. were injected into incisions in the rat corneas using a microsyringe (Badenoch et al. 1990).
The exponential model provided the best fit to the data.
Figure 1: Plot of the exponential model fit to Experiment 1 with upper and lower 95% and 99% confidence
Figure 2: Histogram of the 10,000 bootstrap replicates of k for the best fitting exponential model fit to Experiment 1
Badenoch, P. R., Johnson, A. M., Christy, P. E., & Coster, D. J. (1990). Pathogenicity of Acanthamoeba and a Corynebacterium in the Rat Cornea. Archives of Ophthalmology, 108(1), 107–112. https://doi.org/10.1001/archopht.1990.01070030113040