Experiment ID
Acanth_Cornea1
Pathogen
Contains Preferred Model
0
Status
fitted
Host type
# of Doses
4.00
Μodel
k
1.01E-04
LD50/ID50
6,886
Dose Units
Response
Agent Strain
Acanthamoeba Ac118
Exposure Route
Experiment Dataset
Dose (no. of organisms)Positive ResponsesNegative ResponsesTotal Subjects/Responses
10088
10001616
100021618
10000538
Resampled Parameters
Description: 

Badenoch et al. (1990) studied the combined effect of Acanthamoeba Ac118 (a group III isolate) and the bacterium Corynebacterium xerosis on the corneas of female Porton rats. A constant dose of 104C. xerosis with increasing doses of Acanthamoeba spp. were injected into incisions in the rat corneas using a microsyringe (Badenoch et al. 1990).

The exponential model provided the best fit to the data. 

Figure 1: Plot of the exponential model fit to Experiment 1 with upper and lower 95% and 99% confidence

Figure 2: Histogram of the 10,000 bootstrap replicates of k for the best fitting exponential model fit to Experiment 1

Badenoch, P. R., Johnson, A. M., Christy, P. E., & Coster, D. J. (1990). Pathogenicity of Acanthamoeba and a Corynebacterium in the Rat Cornea. Archives of Ophthalmology, 108(1), 107–112. https://doi.org/10.1001/archopht.1990.01070030113040