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The same exposure route and endpoint was evaluated for Experiments 3 and 4 (Cerva, 1967b; Culbertson et al. 1966). A pooling analysis was attempted and successful. The beta-Poisson model provided a good fit to the pooled data and is shown below in Figure 1. Note: both the exact and approximate beta-Poisson models were fit to the data. The figures shown below and the csv file of bootstrapped parameter replicates are for the best fitting parameters of the exact beta-Poisson model. The successful pooling of multiple datasets generally increases the confidence in the estimated model parameters.
Figure 1: Plot of the beta-Poisson model fit to the pooled Experiments 3 and 4 with upper and lower 95% and 99% confidence
Figure 2: Uncertainty plot of the 10,000 paired bootstrap replicates of alpha and beta for the pooled beta-Poisson model.
Cerva, L. (1967b). Intranasal, Intrapulmonary, and Intracardial Inoculation of Experimental Animals with Hartmanella castellanii. Folia Parasitologica (Praha), 14, 207–215.
Culbertson, C. G., Ensminger, P. W., & Overton, W. M. (1966). Hartmannella (Acanthamoeba): Experimental Chronic, Granulomatous Brain Infections Produced by New Isolates of Low Virulence. The American Journal of Clinical Pathology, 46(3), 305–314.