General overview
Entamoeba coliare a non-pathogenic species of Entamoeba that frequently exists as a commensal parasite in large intestine of the human. Both cysts and trophozoites of the species are passed in stool and considered diagnostic . Cysts are typically found in formed stool, whereas trophozoites are typically found in diarrheal stool. Colonization of the nonpathogenic amebae occurs after ingestion of mature cysts in fecally-contaminated food, water, or fomites .
E. coli is an intestinal protozoa, which belongs to the genus of Entamoeba that cause disease . One of the diseases caused by some species is Amoebiasis, which is defined as infection with the protozoan parasite Entamoeba histolytica.
Summary of Data
Rendtorff, R. C. (1954) studied the Entamoeba coli exposure to human volunteers with a known numbers of cysts of E. coli were administered orally in capsules to volunteers to determine numbers of parasites necessary to establish the infection.
| ID | Exposure Route | # of Doses | Agent Strain | Dose Units | Host type | Μodel | LD50/ID50 | Optimized parameters | Response type | Reference |
|---|---|---|---|---|---|---|---|---|---|---|
| 45 | oral | 5.00 | From an infected human | Cysts | human | beta-Poisson | 3.41E+02 | a = 1.01E-01 N50 = 3.41E+02 | infection |
Rendtorff, R. C. (1954). The experimental transmission of human intestinal protozoan parasites. I. Endamoeba coli cysts given in capsules. American Journal of Hygiene, 59, 2. https://doi.org/https://doi.org/10.1093/oxfordjournals.aje.a119633 |
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Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.
beta Poisson model plot, with confidence bounds around optimized model.