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Experiment ID
18
Pathogen
Burkholderia mallei
Agent Strain
KHW
Contains Preferred Model
No
Reference
Liu, B. ., Koo, G. C., Yap, E. H., Chua, K. L., & Y-h, G. . (2002). Model of Differential Susceptibility to Mucosal Burkholderia pseudomallei Infection. Infection and Immunity, 70, 2.
Exposure Route
intranasal
Response
infection
Host type
C57BL/6 mice
# of Doses
5.00
Dose Units
CFU
Μodel
exponential
k
1.00E-04
LD50/ID50
6.92E+03
Experiment Dataset
Description
C57BL/6 Mice KHW Strain Data 
Dose Infected Non-infected Total
150 0 6 6
450 1 5 6
1350 1 5 6
4050 3 3 6
12200 3 3 6

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential 3.36 2.17 4 3.84 
0.141 		9.49 
0.499
Beta Poisson 1.19 3 7.81 
0.755
Exponential is preferred to beta-Poisson; cannot reject good fit for exponential.

 

Optimized parameters for the exponential model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
k 1E-04 2.87E-05 4.15E-05 4.99E-05 1.89E-04 2.13E-04 2.70E-04
ID50/LD50/ETC* 6.92E+03 2.57E+03 3.26E+03 3.68E+03 1.39E+04 1.67E+04 2.41E+04
*Not a parameter of the exponential model; however, it facilitates comparison with other models.
Parameter histogram for exponential model (uncertainty of the parameter)
Parameter histogram for exponential model (uncertainty of the parameter)
Exponential model plot, with confidence bounds around optimized model
Exponential model plot, with confidence bounds around optimized model

References