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Home / Framework / Dose Response / Experiments / Shigella flexneri: Dose Response Experiments
ID # of Doses Agent Strain Dose Units Host type Μodel Optimized parameters Response type Reference
223 4 2a (strain 2457T) CFU human beta-Poisson a = 1.35E-01

LD50/ID50 = 3.11E+03
N50 = 3.11E+03
illness DuPont, H. L., et al. "Inoculum Size in Shigellosis and Implications for Expected Mode of Transmission." Journal of Infectious Diseases. 159 (1989): 6.
82 5 2a (strain 2457T) CFU human beta-Poisson a = 1.43E-01

LD50/ID50 = 3.54E+04
N50 = 3.54E+04
illness DuPont, H. L., et al. "Immunity in Shigellosis. I. Response of Man to Attenuated Strains of Shigella." Journal of Infectious Diseases. 125 (1972): 1.
82, 223 9 2a (strain 2457T) CFU human beta-Poisson a = 1.17E-01

LD50/ID50 = 3.64E+03
N50 = 3.64E+03
illness DuPont, H. L., et al. "The Response of Man to Virulent Shigella flexneri 2a." Journal of Infectious Diseases. 119 (1969): 3.
83 4 2a (strain 2457T) CFU human beta-Poisson a = 2.65E-01

LD50/ID50 = 1.48E+03
N50 = 1.48E+03
positive stool isolation Altboum, Z., et al. "Postexposure Prophylaxis against Anthrax: Evaluation of Various Treatment Regimens in Intranasally Infected Guinea Pigs." Infection and Immunity. 70 (2002): 11.
Experiment ID:
223
# of Doses:
4
Agent Strain:
2a (strain 2457T)
Dose Units:
CFU
Host type:
human
Μodel:
beta-Poisson
Optimized parameters: a = 1.35E-01

LD50/ID50 = 3.11E+03
N50 = 3.11E+03
Reference:
Experiment ID:
82
# of Doses:
5
Agent Strain:
2a (strain 2457T)
Dose Units:
CFU
Host type:
human
Μodel:
beta-Poisson
Optimized parameters: a = 1.43E-01

LD50/ID50 = 3.54E+04
N50 = 3.54E+04
Reference:
Experiment ID:
82, 223
# of Doses:
9
Agent Strain:
2a (strain 2457T)
Dose Units:
CFU
Host type:
human
Μodel:
beta-Poisson
Optimized parameters: a = 1.17E-01

LD50/ID50 = 3.64E+03
N50 = 3.64E+03
Reference:
Best Fit
Experiment ID:
83
# of Doses:
4
Agent Strain:
2a (strain 2457T)
Dose Units:
CFU
Host type:
human
Μodel:
beta-Poisson
Optimized parameters: a = 2.65E-01

LD50/ID50 = 1.48E+03
N50 = 1.48E+03
Reference: