QMRA Introduction
Hand, Foot, and Mouth Disease caused by enterovirus in China between 2008 and 2009 was studied and the case fatality ratio was 0.03% (Zhang et al, 2011)
Hosts
Human and animal
Transmission / Exposure Route
Fecal-oral, indirectly through contact with dirty hands or objects
Case Fatality Ratio
| Case Fatality Ratio | Pathway/conditions | Population | References |
| 0.03% | Chinese (2008-2009) | [1] | |
| 5-7% | Pre-vaccine era | [2] |
Incubation Period
3-10 days [2]
Burden of Disease
Hand, Foot, and Mouth Disease caused by enterovirus in China between 2008 and 2009 was studied and the incidence rate was 57.9%[1]
Duration of infectiousness and disease
Symptomology
Latency
Asymptomatic Rates
Excretion Rates (see Exposure)
Immunity
Microbiology
Member of the picornavirus family, a large and diverse group of small RNA viruses characterized by a single positive-strand genomic RNA, icosahedral nonenveloped viruses that are approximately 30 nm in diameter[3]
Enviromental Survival
Enteroviruses resist lipid solvents, ether, chloroform, and alcohol. They are inactivated at temperatures above 50°C but remain infectious at refrigerator temperature.[2]
Dose Response Models
Route: oral, Response: infection
exponential
\[P(response)=1-exp(-k\times dose)\]
Optimized parameters:
Data from Other Sources
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