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Experiment ID
Acanth_Cornea2
Agent Strain
Acanthamoeba Ac118
Contains Preferred Model
No
Reference
Badenoch, P. R., Johnson, A. M., Christy, P. E., & Coster, D. J. (1990). Pathogenicity of Acanthamoeba and Corynebacterium in the Rat Cornea. Archives of Ophthalmology, 108, 1. Retrieved from https://jamanetwork.com/journals/jamaophthalmology/article-abstract/638228
Exposure Route
eyes-cornea
Response
infection
Host type
rat
# of Doses
4.00
Dose Units
no of trophozoites
Μodel
exponential
k
3.63E-04
LD50/ID50
1.91E+03
Experiment Dataset
Dose (no. of organisms) Positive Response Negative Response Total Subjects/Responses
10 0 8 8
100 0 16 16
1000 7 17 24
10000 10 0 10
Description

Badenoch et al. (1990) studied the combined effect of Acanthamoeba Ac118 (a group III isolate) and the bacterium Corynebacterium xerosis on the corneas of female Portion rats. A constant dose of 106 C. xerosis with increasing doses of Acanthamoeba spp. were injected into incisions in the rat corneas using a microsyringe.

The exponential model provided the best fit to the data.

Figure 1. Plot of exponential model fit to Experiment 2 with upper and lower 95% and 99% confidence
Figure 1. Plot of exponential model fit to Experiment 2 with upper and lower 95% and 99% confidence
Figure 2. Histogram of the 10,000 bootstrap replicates of k for the best fitting exponential model fit to Experiment 2
Figure 2. Histogram of the 10,000 bootstrap replicates of k for the best fitting exponential model fit to Experiment 2

References

  • Badenoch, P. R., Johnson, A. M., Christy, P. E., & Coster, D. J. (1990). Pathogenicity of Acanthamoeba and Corynebacterium in the Rat Cornea. Archives of Ophthalmology, 108, 1. Retrieved from https://jamanetwork.com/journals/jamaophthalmology/article-abstract/638228