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Experiment ID
23
Pathogen
Burkholderia mallei
Agent Strain
316c
Contains Preferred Model
No
Reference
Brett, P. J., & Woods, D. E. (2000). Pathogenesis of and immunity to melioidosis. Acta Tropica, 74, 2.
Exposure Route
intraperitoneal
Response
death
Host type
diabetic rat
# of Doses
5.00
Dose Units
CFU
Μodel
beta-Poisson
a
2.65E-01
N50
2.27E+03
LD50/ID50
2.27E+03
Experiment Dataset
Description
diabetic rat and 316c strain 
Dose DEATH NOT DEATH Total
3000 6 4 10
3E+04 7 3 10
3E+05 7 3 10
3E+06 10 0 10
3E+07 10 0 10

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential 43.4 39 4 3.84 
4.25e-10 		9.49 
8.61e-09
Beta Poisson 4.39 3 7.81 
0.222
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 500 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 2.65E-01 7.56E-02 1.30E-01 1.54E-01 4.94E-01 5.69E-01 8.88E-01
N50 2.27E+03 7.58E-02 1.50E+01 5.32E+01 8.62E+03 1.11E+04 1.74E+04
Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.
Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.
beta Poisson model plot, with confidence bounds around optimized model
beta Poisson model plot, with confidence bounds around optimized model

References

  • Liu, B. ., Koo, G. C., Yap, E. H., Chua, K. L., & Y-h, G. . (2002). Model of Differential Susceptibility to Mucosal Burkholderia pseudomallei Infection. Infection and Immunity, 70, 2.