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Experiment ID
106
Pathogen
Campylobacter jejuni
Contains Preferred Model
1
Reference
Experimental Campylobacter jejuni Infection in Humans
Host type
human
# of Doses
6.00
Μodel
beta-Poisson
a
1.44E-01
N50
8.9E+02
LD50/ID50
8.9E+02
Dose Units
CFU
Response
infection
Agent Strain
strain A3249
Exposure Route
oral
Experiment Dataset
Description: 
Strain A3249 Data [1]
Dose Infected Non-infected Total
810 5 5 10
8100 6 4 10
91000 11 2 13
810000 8 3 11
1.1E+06 15 4 19
1.1E+08 5 0 5

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value		 χ20.95,m-k 
p-value
Exponential 110 108 5 3.84 
0		 11.1 
0
Beta Poisson 2.43 4 9.49 
0.658
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 1.44E-01 2.05E-02 3.61E-02 4.99E-02 2.66E-01 2.98E-01 3.71E-01
N50 8.9E+02 6.54E-10 1.47E-04 8.11E-02 6.69E+03 8.97E+03 1.53E+04

 

 

 

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

 

beta Poisson model plot, with confidence bounds around optimized model

References

  1. Black, R. E., Levine M. M., Clements M. L., Hughes T. P., & Blaser M. J. (1988).  Experimental Campylobacter jejuni Infection in Humans. Journal of Infectious Diseases. 157, 3.