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Experiment ID
106
Pathogen
Campylobacter jejuni
Agent Strain
strain A3249
Contains Preferred Model
Yes
Reference
Black, R. E., Levine, M. M., Clements, M. L., Hughes, T. P., & Blaser, M. J. (1988). Experimental Campylobacter jejuni Infection in Humans. Journal of Infectious Diseases, 157, 3. https://doi.org/10.1093/infdis/157.3.472
Exposure Route
oral
Response
infection
Host type
human
# of Doses
6.00
Dose Units
CFU
Μodel
beta-Poisson
a
1.44E-01
N50
8.9E+02
LD50/ID50
8.9E+02
Description
Strain A3249 Data 
Dose Infected Non-infected Total
810 5 5 10
8100 6 4 10
91000 11 2 13
810000 8 3 11
1.1E+06 15 4 19
1.1E+08 5 0 5

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value		 χ20.95,m-k 
p-value
Exponential 110 108 5 3.84 
0		 11.1 
0
Beta Poisson 2.43 4 9.49 
0.658
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 1.44E-01 2.05E-02 3.61E-02 4.99E-02 2.66E-01 2.98E-01 3.71E-01
N50 8.9E+02 6.54E-10 1.47E-04 8.11E-02 6.69E+03 8.97E+03 1.53E+04

 

 

 

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

 

beta Poisson model plot, with confidence bounds around optimized model

References

  • Black, R. E., Levine, M. M., Clements, M. L., Hughes, T. P., & Blaser, M. J. (1988). Experimental Campylobacter jejuni Infection in Humans. Journal of Infectious Diseases, 157, 3. https://doi.org/10.1093/infdis/157.3.472