Submitted by admin on

Experiment ID
185
Pathogen
Campylobacter jejuni
Agent Strain
type strain for serotype PEN 2
Contains Preferred Model
No
Reference
Blaser, M. J., Duncan, D. J., Warren, G. H., & W-ll, W. . (1983). Experimental Campylobacter jejuni Infection of Adult Mice. Infection and Immunity, 39, 2.
Exposure Route
intragastric
Response
infection
Host type
mice
# of Doses
5.00
Dose Units
CFU
Μodel
beta-Poisson
a
3.19E-01
N50
6.68E+04
LD50/ID50
6.68E+04
Description
T2 Strain for serotype PEN 2 model data 
Dose Infected Non-infected Total
1E+04 1 4 5
1E+05 3 2 5
1E+06 4 1 5
1E+07 4 1 5
1E+08 5 0 5

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value		 χ20.95,m-k 
p-value
Exponential 25.4 24.5 4 3.84
7.59e-07 		9.49
4.13e-05
Beta Poisson 0.969 3 7.81
0.809
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 3.19E-01 8.29E-02 1.26E-01 1.49E-01 1.05E+01 5.53E+02 1.52E+03
N50 6.68E+04 4.06E+02 5.55E+03 1.04E+04 3.58E+05 4.65E+05 8.48E+05

 

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

 

beta Poisson model plot, with confidence bounds around optimized model

References

  • Black, R. E., Levine, M. M., Clements, M. L., Hughes, T. P., & Blaser, M. J. (1988). Experimental Campylobacter jejuni Infection in Humans. Journal of Infectious Diseases, 157, 3. https://doi.org/10.1093/infdis/157.3.472