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Experiment ID
186
Pathogen
Campylobacter jejuni
Contains Preferred Model
0
Reference
Experimental Campylobacter jejuni Infection of Adult Mice
Host type
mice
# of Doses
5.00
Μodel
beta-Poisson
a
1.17E-01
N50
3.14E+04
LD50/ID50
3.14E+04
Dose Units
CFU
Response
infection
Agent Strain
type strain for serotype PEN 3
Exposure Route
intragastric
Experiment Dataset
Description: 
T3 Strain for serotype PEN 3 model data [1]
Dose Infected Non-infected Total
1E+04 2 3 5
1E+05 4 1 5
1E+06 2 3 5
1E+07 3 2 5
1E+08 5 0 5

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value		 χ20.95,m-k 
p-value
Exponential 45.6 40.2 4 3.84
2.25e-10		 9.49
2.92e-09
Beta Poisson 5.41 3 7.81
0.144
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 1.17E-01 1.06E-02 1.79E-02 2.48E-02 2.79E-01 3.29E-01 4.72E-01
N50 3.14E+04 3.29E-09 2.55E-05 2.53E-02 4.21E+05 9.69E+05 3.68E+06

 

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

 

beta Poisson model plot, with confidence bounds around optimized model

References

  1. Black, R. E., Levine M. M., Clements M. L., Hughes T. P., & Blaser M. J. (1988).  Experimental Campylobacter jejuni Infection in Humans. Journal of Infectious Diseases. 157, 3.