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Experiment ID
186
Pathogen
Campylobacter jejuni
Agent Strain
type strain for serotype PEN 3
Contains Preferred Model
No
Reference
Blaser, M. J., Duncan, D. J., Warren, G. H., & W-ll, W. . (1983). Experimental Campylobacter jejuni Infection of Adult Mice. Infection and Immunity, 39, 2.
Exposure Route
intragastric
Response
infection
Host type
mice
# of Doses
5.00
Dose Units
CFU
Μodel
beta-Poisson
a
1.17E-01
N50
3.14E+04
LD50/ID50
3.14E+04
Description
T3 Strain for serotype PEN 3 model data 
Dose Infected Non-infected Total
1E+04 2 3 5
1E+05 4 1 5
1E+06 2 3 5
1E+07 3 2 5
1E+08 5 0 5

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value		 χ20.95,m-k 
p-value
Exponential 45.6 40.2 4 3.84
2.25e-10 		9.49
2.92e-09
Beta Poisson 5.41 3 7.81
0.144
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 1.17E-01 1.06E-02 1.79E-02 2.48E-02 2.79E-01 3.29E-01 4.72E-01
N50 3.14E+04 3.29E-09 2.55E-05 2.53E-02 4.21E+05 9.69E+05 3.68E+06

 

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

 

beta Poisson model plot, with confidence bounds around optimized model

References

  • Black, R. E., Levine, M. M., Clements, M. L., Hughes, T. P., & Blaser, M. J. (1988). Experimental Campylobacter jejuni Infection in Humans. Journal of Infectious Diseases, 157, 3. https://doi.org/10.1093/infdis/157.3.472