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Experiment ID
28
Pathogen
Coxiella burnetii
Contains Preferred Model
1
Reference
Biological and immunological properties of Coxiella burnetii vaccines in C57BL/10ScN endotoxin-nonresponder mice
Host type
C57BL/1OScN mice
# of Doses
10.00
Μodel
beta-Poisson
a
3.57E-01
N50
4.93E+08
LD50/ID50
4.93E+08
Dose Units
PFU
Response
death
Agent Strain
phase I Ohio
Exposure Route
intraperitoneal
Experiment Dataset
Description: 
Mice/phase I Ohio strain model data [1]
Dose Dead Survived Total
0.7 0 30 30
7 0 20 20
70 0 30 30
7000 0 30 30
7E+05 0 30 30
7E+06 1 19 20
7E+07 6 24 30
7E+08 16 14 30
7E+09 23 7 30
7E+10 19 1 20

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value		 χ20.95,m-k 
p-value
Exponential 73.9 72.8 9 3.84 
0		 16.9 
2.65e-12
Beta Poisson 1.11 8 15.5 
0.997
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 3.57E-01 1.91E-01 2.20E-01 2.38E-01 6.34E-01 7.08E-01 9.84E-01
N50 4.93E+08 1.89E+08 2.41E+08 2.73E+08 9.34E+08 1.06E+09 1.36E+09

 

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

beta Poisson model plot, with confidence bounds around optimized model

 

References

  1. Williams, J. C., & Cantrell J. L. (1982).  Biological and immunological properties of Coxiella burnetii vaccines in C57BL/1OScN endotoxin-nonresponder mice. Infection and Immunity. 35, 1091-1102.