QMRA General overview
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Recommended Model
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| ID | Exposure Route | # of Doses | Agent Strain | Dose Units | Host type | Μodel | LD50/ID50 | Optimized parameters | Response type | Reference |
|---|---|---|---|---|---|---|---|---|---|---|
| ek_intramuscular1 | Intramuscular injection | 3 | E. miricola isolate FL160902 | CFU | beta-Poisson |
α = 0.33 N50 = 2.89E+05 (β = 39,639) |
death | "Pathogenic Elizabethkingia miricola infection in cultured black-spotted frogs, China, 2016." Emerging Infectious Diseases. 23 (2017): 2055. | ||
| ek_intraperitoneal | intraperitoneal | 4 | E. miricola | CFU | beta-Poisson | 4.23E+08 |
α = 0.72 N50 = 4.23E+08 (β = 137,348) |
death | "Elizabethkingia miricola infection in Chinese spiny frog (Quasipaa spinosa)." Transboundary and Emerging Diseases. 66 (2019): 1049-1053. | |
| ek_ intraperitoneal2 | intraperitoneal | 4 | E. anopheles | CFU | exponential | 4.23E+08 |
k = 1.64E-09 |
death | "Isolation and Characterization of a New Phage Infecting Elizabethkingia anophelis and Evaluation of Its Therapeutic Efficacy in vitro and in vivo." Frontiers in Microbiology. 11 (2020). | |
| ek_ pooled | Intramuscular injection and Intraperitoneal injection | 7 | CFU | beta-Poisson | 2.37E+05 [1.06E+05, 5.49E+05] |
α = 0.52 [0.27, 1.53] N50 = 2.37E+05 [1.06E+05, 5.49E+05], β = 86,351 [16,154, 632,550] |
death |
Experiment ID:
ek_intramuscular1
# of Doses:
3
Agent Strain:
E. miricola isolate FL160902
Dose Units:
CFU
Host type:
Μodel:
beta-Poisson
Optimized parameters: a = 0.33
N50 = 2.89E+05 (β = 39,639)
N50 = 2.89E+05 (β = 39,639)
Reference:
Experiment ID:
ek_intraperitoneal
# of Doses:
4
Agent Strain:
E. miricola
Dose Units:
CFU
Host type:
Μodel:
beta-Poisson
Optimized parameters: a = 0.72
LD50/ID50 = 4.23E+08
N50 = 4.23E+08 (β = 137,348)
LD50/ID50 = 4.23E+08
N50 = 4.23E+08 (β = 137,348)
Reference:
Experiment ID:
ek_ intraperitoneal2
# of Doses:
4
Agent Strain:
E. anopheles
Dose Units:
CFU
Host type:
Μodel:
exponential
Optimized parameters:
k = 1.64E-09
LD50/ID50 = 4.23E+08
k = 1.64E-09
LD50/ID50 = 4.23E+08
Reference:
Experiment ID:
ek_ pooled
# of Doses:
7
Agent Strain:
Dose Units:
CFU
Host type:
Μodel:
beta-Poisson
Optimized parameters: a = 0.52 [0.27, 1.53]
LD50/ID50 = 2.37E+05 [1.06E+05, 5.49E+05]
N50 = 2.37E+05 [1.06E+05, 5.49E+05], β = 86,351 [16,154, 632,550]
LD50/ID50 = 2.37E+05 [1.06E+05, 5.49E+05]
N50 = 2.37E+05 [1.06E+05, 5.49E+05], β = 86,351 [16,154, 632,550]
Reference:
