QMRA General overview
Entamoeba coliare a non-pathogenic species of Entamoeba that frequently exists as a commensal parasite in large intestine of the human. Both cysts and trophozoites of the species are passed in stool and considered diagnostic [1]. Cysts are typically found in formed stool, whereas trophozoites are typically found in diarrheal stool. Colonization of the nonpathogenic amebae occurs after ingestion of mature cysts in fecally-contaminated food, water, or fomites [1].
E. coli is an intestinal protozoa, which belongs to the genus of Entamoeba that cause disease [1]. One of the diseases caused by some species is Amoebiasis, which is defined as infection with the protozoan parasite Entamoeba histolytica.
Summary of Data
Rendtorff, R. C. (1954) [2] studied the Entamoeba coli exposure to human volunteers with a known numbers of cysts of E. coli were administered orally in capsules to volunteers to determine numbers of parasites necessary to establish the infection.
References
| ID | # of Doses | Agent Strain | Dose Units | Host type | Μodel | Optimized parameters | Response type | Reference |
|---|---|---|---|---|---|---|---|---|
| 45 | 5 | From an infected human | Cysts | human | beta-Poisson |
a = 1.01E-01 LD50/ID50 = 3.41E+02 N50 = 3.41E+02 |
infection | "The experimental transmission of human intestinal protozoan parasites. I. Endamoeba coli cysts given in capsules." American journal of hygiene. 59 (1954): 2. |
LD50/ID50 = 3.41E+02
N50 = 3.41E+02
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Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.
beta Poisson model plot, with confidence bounds around optimized model.