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Experiment ID
257, 258
Pathogen
Influenza
Contains Preferred Model
1
Reference
Dose Response of Cold-Adapted, Reassortant Influenza A/California/10/78 Virus (H1N1) in Adult Volunteers
Host type
human
# of Doses
9.00
Μodel
beta-Poisson
a
5.81E-01
N50
9.45E+05
LD50/ID50
9.45E+05
Dose Units
TCID50
Response
infection
Agent Strain
H1N1,A/California/10/78 attenuated strain,H3N2,A/Washington/897/80 attenuated strain
Exposure Route
intranasal
Experiment Dataset
Description: 
Pooled dose response data [1]
Dose Infected Non-infected Total
63095.73 0 15 15
1E+05 2 10 12
630957.3 4 7 11
1E+06 8 5 13
6309573 19 3 22
1E+07 16 3 19
31622777 16 4 20
63095734 24 1 25
1E+08 19 0 19

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value		 χ20.95,m-k 
p-value
Exponential 64 55.4 8 3.84 
9.68e-14		 15.5 
7.63e-11
Beta Poisson 8.56 7 14.1 
0.285
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 5.81E-01 3.61E-01 3.98E-01 4.24E-01 9.15E-01 1.02E+00 1.36E+00
N50 9.45E+05 4.38E+05 5.28E+05 5.72E+05 1.62E+06 1.79E+06 2.23E+06

 

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

beta Poisson model plot, with confidence bounds around optimized model