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Experiment ID
258
Pathogen
Influenza
Contains Preferred Model
0
Reference
Two amino acid residues in the matrix protein M1 contribute to the virulence difference of H5N1 avian influenza viruses in mice
Host type
human
# of Doses
5.00
Μodel
beta-Poisson
a
4.29E-01
N50
6.66E+05
LD50/ID50
6.66E+05
Dose Units
TCID50
Response
infection
Agent Strain
H3N2,A/Washington/897/80 attenuated strain
Exposure Route
intranasal
Experiment Dataset
Description: 
human/H3N2, A/Washington/897/80 attenuated strain model data [3]
Dose Infected Non-infected Total
1E+05 2 10 12
1E+06 8 5 13
1E+07 16 3 19
31622777 16 4 20
1E+08 19 0 19

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value		 χ20.95,m-k 
p-value
Exponential 39.1 34.8 4 3.84 
3.66e-09		 9.49 
6.79e-08
Beta Poisson 4.26 3 7.81 
0.235
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 4.29E-01 2.14E-01 2.58E-01 2.83E-01 7.58E-01 8.71E-01 1.20E+00
N50 6.66E+05 1.36E+05 2.19E+05 2.68E+05 1.63E+06 1.87E+06 2.49E+06

 

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

beta Poisson model plot, with confidence bounds around optimized model