Optimization Output for Exp. 242

Basic Information

Experiment ID	242
Pathogen	Legionella pneumophila
Contains Preferred Model	0
Reference	Guinea pigs sublethally infected with aerosolized Legionella pneumophila develop humoral and cell-mediated immune responses and are protected against lethal aerosol challenge. A model for studying host defense against lung infections caused by intracellul

Detailed information

Host type

# of Doses

4.00

Μodel

6.48E-05

LD50/ID50

1.07E+04

Dose Units

Response

Agent Strain

strain 74/81

Exposure Route

Experiment Dataset

Description:

**Goodness of fit and model selection**
Model	Deviance	Δ	Degrees of freedom	χ²_0.95,1 p-value	χ²_0.95,m-k p-value
Exponential	2.34	-0.00145	3	3.84 1	7.81 0.506
Beta Poisson	2.34	-0.00145	2	3.84 1	5.99 0.311
Exponential is preferred to beta-Poisson; cannot reject good fit for exponential.

**Optimized k parameter for the exponential model, from 10000 bootstrap iterations**
Parameter	MLE estimate	Percentiles
Parameter	MLE estimate	0.5%	2.5%	5%	95%	97.5%	99.5%
k	6.48E-05	5.45E-05	5.45E-05	5.45E-05	9.71E-05	9.71E-05	1.24E-04
ID50/LD50/ETC*	1.07E+04	5.57E+03	7.14E+03	7.14E+03	1.27E+04	1.27E+04	1.27E+04
*Not a parameter of the exponential model; however, it facilitates comparison with other models.

Parameter histogram for exponential model (uncertainty of the parameter)

Exponential model plot, with confidence bounds around optimized model

References