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Experiment ID
263
Pathogen
Mycobacterium avium
Agent Strain
sub sp. Paratuberculosis IOI strain
Contains Preferred Model
No
Reference
Badenoch, P. R., Johnson, A. M., Christy, P. E., & Coster, D. J. (1990). Pathogenicity of Acanthamoeba and Corynebacterium in the Rat Cornea. Archives of Ophthalmology, 108, 1. Retrieved from https://jamanetwork.com/journals/jamaophthalmology/article-abstract/638228
Exposure Route
oral
Response
infection
Host type
cheviots
# of Doses
3.00
Dose Units
CFU
Μodel
beta-Poisson
a
5.79E-02
N50
4.8E+02
LD50/ID50
4.8E+02
Description
Dose response data
Dose Infected Non-infected Total
100 6 6 12
1E+05 6 6 12
1E+08 10 2 12

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential 193 192 2 3.84 
0 		5.99 
0
Beta Poisson 1.43 1 3.84 
0.231
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 5.79E-02 9.94E-04 9.78E-03 1.25E-02 1.27E-01 1.42E-01 1.87E-01
N50 4.8E+02 3.44E-13 5.25E-08 1.89E-05 5.61E+04 1.50E+05 4.41E+06

 

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters

beta Poisson model plot, with confidence bounds around optimized model

References

  • Brotherston, J. G., Gilmour, N. J., & Samuel, J. . (1961). Quantitative studies of Mycobacterium johnei in the tissues of sheep. Journal of Comparative Pathology, 71, 286. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/14317616