Optimization Output for Exp. 68

Basic Information

Experiment ID	68
Pathogen	Rotavirus
Contains Preferred Model	0
Reference	Minimal infective dose of the OSU strain of porcine rotavirus

Detailed information

Host type

# of Doses

10.00

Μodel

1.73E-02

LD50/ID50

4E+01

Dose Units

Response

Agent Strain

OSU (ATCC VR892)

Exposure Route

Experiment Dataset

Description:

**Goodness of fit and model selection**
Model	Deviance	Δ	Degrees of freedom	χ²_0.95,1 p-value	χ²_0.95,m-k p-value
Exponential	1.1	-0.0019	9	3.84 1	16.9 0.999
Beta Poisson	1.1	-0.0019	8	3.84 1	15.5 0.998
Exponential is preferred to beta-Poisson; cannot reject good fit for exponential.

**Optimized k parameter for the exponential model, from 10000 bootstrap iterations**
Parameter	MLE estimate	Percentiles
Parameter	MLE estimate	0.5%	2.5%	5%	95%	97.5%	99.5%
k	1.73E-02	4.64E-03	7.21E-03	7.21E-03	3.28E-02	3.28E-02	3.28E-02
ID50/LD50/ETC*	4E+01	2.11E+01	2.11E+01	2.11E+01	9.61E+01	9.61E+01	1.49E+02
*Not a parameter of the exponential model; however, it facilitates comparison with other models.

Parameter histogram for exponential model (uncertainty of the parameter)

Exponential model plot, with confidence bounds around optimized model

References