Optimization Output for Exp. 235

Basic Information

Experiment ID	235
Pathogen	Salmonella newport
Contains Preferred Model	1
Reference	Experimental Human Salmonellosis: I. Pathogenicity of Strains of Salmonella Meleagridis and Salmonella Anatum Obtained from Spray-Dried Whole Egg

Detailed information

Host type

# of Doses

3.00

Μodel

3.97E-06

LD50/ID50

1.74E+05

Dose Units

Response

Agent Strain

*Salmonella newport*

Exposure Route

Experiment Dataset

Description:

**Goodness of fit and model selection**
Model	Deviance	Δ	Degrees of freedom	χ²_0.95,1 p-value	χ²_0.95,m-k p-value
Exponential	0.16	-3.32e-05	2	3.84 1	5.99 0.923
Beta Poisson	0.16	-3.32e-05	1	3.84 1	3.84 0.689
Exponential is preferred to beta-Poisson; cannot reject good fit for exponential.

**Optimized k parameter for the exponential model, from 10000 bootstrap iterations**
Parameter	MLE estimate	Percentiles
Parameter	MLE estimate	0.5%	2.5%	5%	95%	97.5%	99.5%
k	3.97E-06	1.75E-06	2.16E-06	2.32E-06	7.36E-06	9.04E-06	1.27E-05
ID50/LD50/ETC*	1.74E+05	5.45E+04	7.67E+04	9.41E+04	2.98E+05	3.20E+05	3.97E+05
*Not a parameter of the exponential model; however, it facilitates comparison with other models.

Parameter histogram for exponential model (uncertainty of the parameter)

Exponential model plot, with confidence bounds around optimized model

References