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Experiment ID
249
Pathogen
Vibrio cholerae
Agent Strain
Inaba 569B
Contains Preferred Model
Yes
Reference
Diringer, H. ., Roehmel, J. ., & Beekes, M. . (1998). Effect of repeated oral infection of hamsters with scrapie. Journal of General Virology, 79. Retrieved from http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.541.3587&rep=rep1&type=pdf
Exposure Route
oral (with NaHCO3)
Response
infection
Host type
human
# of Doses
6.00
Dose Units
CFU
Μodel
beta-Poisson
a
2.50E-01
N50
2.43E+02
LD50/ID50
2.43E+02
Description
Human Inaba Strain 569B  
Dose Infected Non-infected Total
10 0 2 2
1000 3 1 4
1E+04 11 2 13
1E+05 7 1 8
1E+06 21 2 23
1E+08 2 0 2

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential 92.4 91.2 5 3.84 
0 		11.1 
0
Beta Poisson 1.16 4 9.49 
0.885
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 2.5E-01 1.14E-01 1.48E-01 1.66E-01 5.44E-01 6.55E-01 2.91E+00
N50 2.43E+02 1.88E+01 4.82E+01 6.35E+01 1.52E+03 2.08E+03 3.60E+03

 

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

beta Poisson model plot, with confidence bounds around optimized model

References

  • Hornick, R. B., Music, S. I., Wenzel, R. ., Cash, R. ., Libonati, J. P., Snyder, M. J., & Woodward, T. E. (1971). The Broad Street pump revisited: response of volunteers to ingested cholera vibrios. Bulletin of the New York Academy of Medicine, 47, 10. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1749960/