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Experiment ID
70
Pathogen
Rotavirus
Contains Preferred Model
1
Reference
Human Rotavirus Studies in Volunteers: Determination of Infectious Dose and Serological Response to Infection
Host type
human
# of Doses
8.00
Μodel
beta-Poisson
a
2.53E-02
N50
6.17E+00
LD50/ID50
6.17E+00
Dose Units
FFU
Exposure Route
oral
Experiment Dataset
Description: 
Model data for rotavirus (CJN strain) in the human [1]
Dose Infected Non-infected Total
9E-03 0 7 7
0.09 0 7 7
0.9 1 6 7
9 8 3 11
90 6 1 7
900 7 1 8
9000 5 2 7
9E+04 3 0 3

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value		 χ20.95,m-k 
p-value
Exponential 125 119 7 3.84 
0		 14.1 
0
Beta Poisson 6.2 6 12.6 
0.401
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 2.53E-01 1.28E-01 1.51E-01 1.64E-01 5.18E-01 6.58E-01 6.76E+02
N50 6.17E+00 1.46E+00 2.17E+00 2.49E+00 1.89E+01 2.49E+01 4.37E+01

 

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters

beta Poisson model plot, with confidence bounds around optimized model

References

  1. Ward, R. L., Bernstein D. I., Young E. C., Sherwood J. R., Knowlton D. R., & Schiff G. M. (1986).  Human Rotavirus Studies in Volunteers: Determination of Infectious Dose and Serological Response to Infection. Journal of Infectious Diseases. 154, 5.