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Experiment ID
184
Pathogen
Campylobacter jejuni
Contains Preferred Model
0
Reference
Experimental Campylobacter jejuni Infection of Adult Mice
Host type
mice
# of Doses
5.00
Μodel
exponential
k
9.01E-07
LD50/ID50
7.69E+05
Dose Units
CFU
Response
infection
Agent Strain
type strain for serotype PEN 1
Exposure Route
intragastric
Experiment Dataset
Description: 
T1 Strain for serotype PEN 1 data [1]
Dose Infected Non-infected Total
1 0 5 5
100 0 5 5
1E+04 0 5 5
1E+06 3 2 5
1E+08 5 0 5

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value		 χ20.95,m-k 
p-value
Exponential 0.0918 -0.000599 4 3.84
1		 9.49
0.999
Beta Poisson 0.0924 3 7.81
0.993
Exponential is preferred to beta-Poisson; cannot reject good fit for exponential.

 

Optimized k parameter for the exponential model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
k 9.01E-07 4.61E-08 2.21E-07 2.21E-07 4.61E-06 4.61E-06 4.61E-06
ID50/LD50/ETC* 7.69E+05 1.51E+05 1.51E+05 1.51E+05 3.14E+06 3.14E+06 1.51E+07
*Not a parameter of the exponential model; however, it facilitates comparison with other models.

 

 

 

Parameter histogram for exponential model (uncertainty of the parameter)

 

Exponential model plot, with confidence bounds around optimized model

References

  1. Blaser, M. J., Duncan D. J., Warren G. H., & W-ll W. (1983).  Experimental Campylobacter jejuni Infection of Adult Mice. Infection and Immunity. 39, 2.