Submitted by admin on

Experiment ID
188
Pathogen
Campylobacter jejuni
Agent Strain
strain 81-176
Contains Preferred Model
No
Reference
Tribble, D. R., Baqar, S. ., Scott, D. A., Oplinger, M. L., Trespalacios, F. ., Rollins, D. ., … Bourgeois, A. L. (2010). Assessment of the Duration of Protection in Campylobacter jejuni Experimental Infection in Humans. Infection and Immunity, 78, 4.
Exposure Route
oral (w. 2g NaHCO3)
Response
campylobacteriosis
Host type
human
# of Doses
3.00
Dose Units
CFU
Μodel
beta-Poisson
a
1.66E-01
N50
1.23E+05
LD50/ID50
1.23E+05
Description
Strain 81-176 model data 
Dose Campylobacteriosis Non-campylobacteriosis Total
1E+05 3 2 5
1E+07 2 3 5
1E+09 33 3 36

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value		 χ20.95,m-k 
p-value
Exponential 50.1 46.6 2 3.84
8.56e-12 		5.99
1.29e-11
Beta Poisson 3.51 1 3.84
0.061
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 1.66E-01 2.92E-02 4.29E-02 6.44E-02 3.32E-01 4.07E-01 1.16E+00
N50 1.23E+05 6.24E-10 4.60E-05 9.04E-01 2.00E+06 6.12E+06 3.96E+07

 

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

 

beta Poisson model plot, with confidence bounds around optimized model

References

  • Tribble, D. R., Baqar, S. ., Scott, D. A., Oplinger, M. L., Trespalacios, F. ., Rollins, D. ., … Bourgeois, A. L. (2010). Assessment of the Duration of Protection in Campylobacter jejuni Experimental Infection in Humans. Infection and Immunity, 78, 4.