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Experiment ID
21
Pathogen
Burkholderia mallei
Contains Preferred Model
0
Reference
Studies on Certain Biological Characteristics of Malleomyces mallei and Malleomyces pseudomallei
Host type
guinea pig
# of Doses
6.00
Μodel
beta-Poisson
a
2.67E-01
N50
2.55E+02
LD50/ID50
2.55E+02
Dose Units
CFU
Response
death
Agent Strain
W294
Exposure Route
intraperitoneal
Experiment Dataset
Description: 
Guinea Pigs W294 Strain Data [1]
Dose Dead Survived Total
44 1 4 5
440 3 2 5
4400 4 1 5
44000 5 0 5
440000 5 0 5
4.4E+06 4 1 5

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value		 χ20.95,m-k 
p-value
Exponential 70.3 66.1 5 3.84 
4.44e-16		 11.1 
8.93e-14
Beta Poisson 4.14 4 9.49 
0.387
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 2.67E-01 3.36E-02 8.80E-02 1.16E-01 1.05E+01 3.45E+02 3.55E+03
N50 2.55E+02 4.80E-07 2.49E+00 1.48E+01 1.35E+03 1.80E+03 3.22E+03

 

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

beta Poisson model plot, with confidence bounds around optimized model

References

  1. Miller, W. R., Pannell L., Cravitz L., Tanner W. A., & Rosebury T. (1948).  Studies on Certain Biological Characteristics of Malleomyces mallei and Malleomyces pseudomallei. Journal of Bacteriology. 55, 1.