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Experiment ID
23
Pathogen
Burkholderia mallei
Contains Preferred Model
0
Reference
Pathogenesis of and immunity to melioidosis
Host type
diabetic rat
# of Doses
5.00
Μodel
beta-Poisson
a
2.65E-01
N50
2.27E+03
LD50/ID50
2.27E+03
Dose Units
CFU
Response
death
Agent Strain
316c
Exposure Route
intraperitoneal
Experiment Dataset
Description: 
diabetic rat and 316c strain [1]
Dose DEATH NOT DEATH Total
3000 6 4 10
3E+04 7 3 10
3E+05 7 3 10
3E+06 10 0 10
3E+07 10 0 10

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value		 χ20.95,m-k 
p-value
Exponential 43.4 39 4 3.84 
4.25e-10		 9.49 
8.61e-09
Beta Poisson 4.39 3 7.81 
0.222
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 500 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 2.65E-01 7.56E-02 1.30E-01 1.54E-01 4.94E-01 5.69E-01 8.88E-01
N50 2.27E+03 7.58E-02 1.50E+01 5.32E+01 8.62E+03 1.11E+04 1.74E+04

 

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

 

beta Poisson model plot, with confidence bounds around optimized model

References