Optimization Output for Exp. 255

Basic Information

Experiment ID	255
Pathogen	Adenovirus
Contains Preferred Model	0
Reference	Studies of echovirus-12 in volunteers: determination of minimal infectious dose and the effect of previous infection on infectious dose

Detailed information

Host type

# of Doses

5.00

Μodel

1.51E-02

LD50/ID50

4.59E+01

Dose Units

Response

Agent Strain

type 4

Exposure Route

Experiment Dataset

Description:

**Goodness of fit and model selection**
Model	Deviance	Δ	Degrees of freedom	χ²_0.95,1 p-value	χ²_0.95,m-k p-value
Exponential	2.14	-0.00118	4	3.84 1	9.49 0.71
Beta Poisson	2.14	-0.00118	3	3.84 1	7.81 0.544
Exponential is preferred to beta-Poisson; cannot reject good fit for exponential.

**Optimized k parameter for the exponential model, from 10000 bootstrap iterations**
Parameter	MLE estimate	Percentiles
Parameter	MLE estimate	0.5%	2.5%	5%	95%	97.5%	99.5%
k	1.51E-02	4.00E-03	5.88E-03	6.35E-03	4.56E-02	4.56E-02	4.56E-02
ID50/LD50/ETC*	4.59E+01	1.52E+01	1.52E+01	1.52E+01	1.09E+02	1.18E+02	1.73E+02
*Not a parameter of the exponential model; however, it facilitates comparison with other models.

Parameter histogram for exponential model (uncertainty of the parameter)

Exponential model plot, with confidence bounds around optimized model

References