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Experiment ID
263
Pathogen
Mycobacterium avium
Contains Preferred Model
0
Reference
Pathogenicity of Acanthamoeba and Corynebacterium in the Rat Cornea
Host type
cheviots
# of Doses
3.00
Μodel
beta-Poisson
a
5.79E-02
N50
4.8E+02
LD50/ID50
4.8E+02
Dose Units
CFU
Response
infection
Agent Strain
sub sp. Paratuberculosis IOI strain
Exposure Route
oral
Experiment Dataset
Description: 
Dose response data [1]
Dose Infected Non-infected Total
100 6 6 12
1E+05 6 6 12
1E+08 10 2 12

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value		 χ20.95,m-k 
p-value
Exponential 193 192 2 3.84 
0		 5.99 
0
Beta Poisson 1.43 1 3.84 
0.231
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 5.79E-02 9.94E-04 9.78E-03 1.25E-02 1.27E-01 1.42E-01 1.87E-01
N50 4.8E+02 3.44E-13 5.25E-08 1.89E-05 5.61E+04 1.50E+05 4.41E+06

 

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters

beta Poisson model plot, with confidence bounds around optimized model

References