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Experiment ID
181
Pathogen
Cryptosporidium hominis
Cryptosporidium parvum
Agent Strain
*C. hominis*, TU502
Contains Preferred Model
No
Reference
Okhuysen, P. C., Rich, S. M., Chappell, C. L., Grimes, K. A., Widmer, G. ., Feng, X. ., & Tzipori, S. . (2002). Infectivity of a Cryptosporidium parvum Isolate of Cervine Origin for Healthy Adults and Interferon-γ Knockout Mice. Journal of Infectious Diseases, 185, 9. Retrieved from https://academic.oup.com/jid/article/185/9/1320/937719
Exposure Route
oral
Response
diarrhea
Host type
human
# of Doses
4.00
Dose Units
oocysts
Μodel
beta-Poisson
a
2.7E-01
N50
1.68E+01
LD50/ID50
1.68E+01
Description
TU502 data 
Dose Diarrhea Not diarrhea Total
10 2 3 5
30 3 2 5
100 5 2 7
500 3 1 4

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential 11.6 11.5 3 3.84 
0.000708 		7.81 
0.00894
Beta Poisson 0.119 2 5.99 
0.942
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 2.7E-01 9.83E-04 9.85E-04 2.03E-03 6.60E+00 6.70E+02 3.19E+03
N50 1.68E+01 3.41E-16 9.86E-09 1.68E-06 7.15E+01 9.76E+01 6.59E+02

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

beta Poisson model plot, with confidence bounds around optimized model.

References

  • Chappell, C. L., Okhuysen, P. C., Langer-Curry, R. ., Widmer, G. ., Akiyoshi, D. E., Tanriverdi, S. ., & Tzipori, S. . (2006). Cryptosporidium Hominis: Experimental Challenge of Healthy Adults. The American Journal of Tropical Medicine and Hygiene, 75, 5. Retrieved from http://www.ajtmh.org/content/journals/10.4269/ajtmh.2006.75.851