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Experiment ID
183
Pathogen
Cryptosporidium hominis
Cryptosporidium parvum
Agent Strain
Moredun isolate
Contains Preferred Model
No
Reference
Blaser, M. J., Duncan, D. J., Warren, G. H., & W-ll, W. . (1983). Experimental Campylobacter jejuni Infection of Adult Mice. Infection and Immunity, 39, 2.
Exposure Route
oral
Response
infection
Host type
human
# of Doses
4.00
Dose Units
oocysts
Μodel
beta-Poisson
a
1.14E-01
N50
4.55E+02
LD50/ID50
4.55E+02
Description
Moredunn isolate data 
Dose Infected Non-infected Total
100 2 2 4
300 2 3 5
1000 1 2 3
3000 3 1 4

 

Goodness of fit and model selection
Model Deviance Δ Degrees 
of freedom		 χ20.95,1 
p-value 		χ20.95,m-k 
p-value
Exponential 7.37 6.16 3 3.84 
0.0131 		7.81 
0.0611
Beta Poisson 1.21 2 5.99 
0.546
Beta-Poisson fits better than exponential; cannot reject good fit for beta-Poisson.

 

Optimized parameters for the beta-Poisson model, from 10000 bootstrap iterations
Parameter MLE estimate Percentiles
0.5% 2.5% 5% 95% 97.5% 99.5%
α 1.14E-01 9.79E-04 9.81E-04 9.82E-04 1.17E+03 2.25E+03 5.52E+03
N50 4.55E+02 2.13E-09 2.19E-06 1.55E-05 5.62E+05 3.59E+09 1.43E+16

Parameter scatter plot for beta Poisson model ellipses signify the 0.9, 0.95 and 0.99 confidence of the parameters.

beta Poisson model plot, with confidence bounds around optimized model.

References

  • Okhuysen, P. C., Rich, S. M., Chappell, C. L., Grimes, K. A., Widmer, G. ., Feng, X. ., & Tzipori, S. . (2002). Infectivity of a Cryptosporidium parvum Isolate of Cervine Origin for Healthy Adults and Interferon-γ Knockout Mice. Journal of Infectious Diseases, 185, 9. Retrieved from https://academic.oup.com/jid/article/185/9/1320/937719